1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Base Information

Chemical Name:1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine
CAS No.:129678-53-1
Molecular Formula:C₂₇H₃₂N₂O₆Si
Molecular Weight:508.646
Hs Code.:

Synonyms:1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Suppliers and Price of 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

There total 5 articles about 1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 129678-64-4
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-β-D-arabino-pentofuranosyl>thymine

: 129678-53-1
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: With mercury dichloride; mercury(II) oxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;
DOI:10.1021/jm00171a025

Reference yield:

: 115913-84-3
1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine

: 129678-53-1
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) hexamethylphosphoramide (HMPA), n-butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.) 90 min

2: 69 percent / dichloroacetic acid / CH₂Cl₂ / 0.17 h

3: 67 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / dimethylformamide / Ambient temperature

4: 90 percent / red mercuric oxide, mercuric chloride / tetrahydrofuran; H₂O / 0.08 h / 0 °C

With dichloro-acetic acid; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; triethylamine; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a025

Reference yield:

: 130468-30-3
1-<3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-β-D-arabino-pentofuranosyl>thymine

: 129678-53-1
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-formyl-β-D-arabino-pentofuranosyl>thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / dimethylformamide / Ambient temperature

2: 90 percent / red mercuric oxide, mercuric chloride / tetrahydrofuran; H₂O / 0.08 h / 0 °C

With dmap; triethylamine; mercury dichloride; mercury(II) oxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a025