129678-64-4Relevant academic research and scientific papers
Synthesis of 2′-Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs
Peoc'h, Didier,Swayze, Eric E.,Bhat, Balkrishen,Sanghvi, Yogesh S.
, p. 411 - 438 (2007/10/03)
The synthesis of a series of methylene(methylimino) (MMI) linked oligodeoxyribonucleotide dimers modified at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2
Synthesis of antiviral activity of 3'-deoxy-3'-C-hydroxymethyl nucleosides
Bamford,Coe,Walker
, p. 2494 - 2501 (2007/10/02)
A series of 3'-branched-chain sugar nucleosides, in particular 3'-deoxy-3'-C-hydroxymethyl nucleosides, have been synthesized and evaluated as antiviral agents. Reaction of 1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentafuranosyl) derivatives 12 and 13, of uracil
