methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

Base Information

Chemical Name:methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)
CAS No.:1621105-54-1
Molecular Formula:C₃₀H₄₀N₄O₆
Molecular Weight:552.671
Hs Code.:

Synonyms:methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

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Chemical Property of methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

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Technology Process of methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

There total 2 articles about methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1621105-16-5
allyl (S)-4-(N-benzyl-2-((tert-butoxycarbonyl)amino)-4-methoxy-4-oxobutanamido)-4-(benzylcarbamoyl)piperidine-1-carboxylate

: 1621105-54-1
methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.06.026

Reference yield:

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 59768-74-0,124184-67-4
(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester

: 100-46-9
benzylamine

: 306296-67-3
1-allyloxycarbonylpiperidin-4-one

: 1621105-54-1
methyl (S)-4-(benzyl(4-(benzylcarbamoyl)piperidin-4-yl)amino)-3-((tert-butoxycarbonyl)amino-4-oxobutanoate)

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 96 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In methanol; dichloromethane; 1.1: |Ugi Condensation;
DOI:10.1016/j.ejmech.2014.06.026