(4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol

Base Information

• Chemical Name: (4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol
• CAS No.: 1638754-75-2
• Molecular Formula: C₂₀H₂₄O₃Si
• Molecular Weight: 340.494
• Mol file: 1638754-75-2.mol

Synonyms:(4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol

Chemical Property of (4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol

There total 1 articles about (4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bromobenzene (108-86-1,52753-63-6) + 4,5-dimethoxy-2-((trimethylsilyl)ethynyl)benzaldehyde (106824-48-0) → (4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol (1638754-75-2)

Guidance literature:

bromobenzene; With iodine; magnesium;

4,5-dimethoxy-2-(2-trimethylsilylethynyl)benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1002/chem.201403040

Reference yield:

(4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol (1638754-75-2) + methyl iodide (74-88-4) → C21H26O3Si

Guidance literature:

(4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.166667h; Cooling with ice;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

DOI:10.1002/chem.201403040

Reference yield:

(4,5-dimethoxy-2-((trimethylsilyl)ethynyl)phenyl)(phenyl)methanol (1638754-75-2) → 1-(bromoethynyl)-4,5-dimethoxy-2-(methoxy(phenyl)methyl)benzene (1638755-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Cooling with ice

1.2: 2 h / 20 °C

2.1: potassium carbonate; methanol / 1 h / 20 °C

3.1: N-Bromosuccinimide; silver nitrate / acetone / 1 h / 20 °C

With methanol; N-Bromosuccinimide; sodium hydride; potassium carbonate; silver nitrate; In tetrahydrofuran; acetone; mineral oil;

DOI:10.1002/chem.201403040

upstream raw materials:

bromobenzene

4,5-dimethoxy-2-((trimethylsilyl)ethynyl)benzaldehyde

Downstream raw materials:

1-(bromoethynyl)-4,5-dimethoxy-2-(methoxy(phenyl)methyl)benzene

3-(2,5,6-trimethoxy-3-phenyl-1H-inden-1-yl)oxazolidin-2-one

1-ethynyl-4,5-dimethoxy-2-(methoxy(phenyl)methyl)benzene

3-((4,5-dimethoxy-2-(methoxy(phenyl)methyl)phenyl)ethynyl)oxazolidin-2-one