4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Base Information

Chemical Name:4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester
CAS No.:876954-06-2
Molecular Formula:C₅₁H₈₇N₅O₁₂Si
Molecular Weight:990.364
Hs Code.:

4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-<i>tert</i>-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Synonyms:4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

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Chemical Property of 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

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Technology Process of 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

There total 13 articles about 4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 876954-05-1
C₅₉H₉₃N₅O₁₄Si

: 876954-06-2
4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; under 760.051 Torr;
DOI:10.1021/jo070412r

Reference yield:

: 766513-72-8
C₆₅H₁₀₇N₅O₁₅Si₂

: 876954-06-2
4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 130 mg / MgBr₂*Et₂O / CH₂Cl₂ / 0 - 20 °C

2: 78 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

With hydrogen; magnesium bromide; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r

Reference yield:

: 766513-71-7
(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Amino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 876954-06-2
4-amino-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-phenyl-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / DIEA; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 130 mg / MgBr₂*Et₂O / CH₂Cl₂ / 0 - 20 °C

3: 78 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; magnesium bromide; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r