(S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate

Base Information

• Chemical Name: (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate
• CAS No.: 128054-98-8
• Molecular Formula: C₂₈H₂₈F₂O₅
• Molecular Weight: 482.524
• Mol file: 128054-98-8.mol

Synonyms:(S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate

Chemical Property of (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate

There total 4 articles about (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-(-)-4-<<<1-(difluoromethyl)heptyl>oxy>carbonyl>phenyl 4'-(benzyloxy)biphenyl-4-carboxylate (128054-99-9) → (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate (128054-98-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 5h; Irradiation;

DOI:10.1021/ja00174a023

Reference yield:

4-benzyloxy-biphenyl-4'-carboxylic acid chloride (111153-17-4) → (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate (128054-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 72 h / Ambient temperature

2: 81 percent / H₂ / 10percent Pd/C / ethanol / 5 h / Irradiation

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja00174a023

Reference yield:

4'-(Benzyloxy)-biphenyl-4-carboxylic acid (111153-16-3) → (S)-(-)-4-<<<1-(difluoromethyl)octyl>oxy>carbonyl>phenyl 4'-hydroxybiphenyl-4-carboxylate (128054-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / Heating

2: pyridine / CH₂Cl₂ / 72 h / Ambient temperature

3: 81 percent / H₂ / 10percent Pd/C / ethanol / 5 h / Irradiation

With pyridine; thionyl chloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja00174a023

upstream raw materials:

(S)-(-)-4-<<<1-(difluoromethyl)heptyl>oxy>carbonyl>phenyl 4'-(benzyloxy)biphenyl-4-carboxylate

4-benzyloxy-biphenyl-4'-carboxylic acid chloride

4'-(Benzyloxy)-biphenyl-4-carboxylic acid

(S)-(-)-1-(difluoromethyl)heptyl p-hydroxybenzoate

Downstream raw materials:

4'-(12-Acryloyloxy-dodecyloxy)-biphenyl-4-carboxylic acid 4-((S)-1-difluoromethyl-heptyloxycarbonyl)-phenyl ester

4'-(8-Acryloyloxy-octyloxy)-biphenyl-4-carboxylic acid 4-((S)-1-difluoromethyl-heptyloxycarbonyl)-phenyl ester

4'-(6-Acryloyloxy-hexyloxy)-biphenyl-4-carboxylic acid 4-((S)-1-difluoromethyl-heptyloxycarbonyl)-phenyl ester

4'-(2-Acryloyloxy-ethoxy)-biphenyl-4-carboxylic acid 4-((S)-1-difluoromethyl-heptyloxycarbonyl)-phenyl ester