3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Base Information

Chemical Name:3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole
CAS No.:259667-87-3
Molecular Formula:C₂₁H₂₁ClF₃IN₂O₂
Molecular Weight:552.763
Hs Code.:

Synonyms:3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Suppliers and Price of 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

There total 4 articles about 3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-46-4
3-trifluoromethylnitrobenzene

: 259667-87-3
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 21 percent / N-iodosuccimide; conc. H₂SO₄ / 6 h / 50 °C

2.1: 80 percent / SnCl₂*H₂O / ethanol / 1 h / Heating

3.1: diethyl ether; toluene / 0.33 h / 20 °C

3.2: chiral HPLC

With N-iodo-succinimide; sulfuric acid; tin(ll) chloride; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm0103763

Reference yield:

: 41253-01-4
1-iodo-3-nitro-5-(trifluoromethyl)benzene

: 259667-87-3
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / SnCl₂*H₂O / ethanol / 1 h / Heating

2.1: diethyl ether; toluene / 0.33 h / 20 °C

2.2: chiral HPLC

With tin(ll) chloride; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm0103763

Reference yield:

: 36692-27-0
2-chlorophenylmagnesium bromide

: 259667-63-5
1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin

: 259667-87-3
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(S)-hydroxy-6-iodo-4-trifluoromethyloxindole

: 259667-88-4
3-(2-chlorophenyl)-1-(2-diethylaminoethyl)-3(R)-hydroxy-6-iodo-4-trifluoromethyloxindole

Guidance literature:: 2-chlorophenylmagnesium bromide; 1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin; In diethyl ether; toluene; at 20 ℃; for 0.333333h;

Further stages. Title compound not separated from byproducts.; chiral HPLC;
DOI:10.1021/jm0103763