5-([1,1'-biphenyl]-4-yl)oxazole

Base Information

• Chemical Name: 5-([1,1'-biphenyl]-4-yl)oxazole
• CAS No.: 1145-12-6
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.258
• Mol file: 1145-12-6.mol

Synonyms:5-([1,1'-biphenyl]-4-yl)oxazole

Chemical Property of 5-([1,1'-biphenyl]-4-yl)oxazole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-([1,1'-Biphenyl]-4-yl)oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-([1,1'-biphenyl]-4-yl)oxazole

There total 5 articles about 5-([1,1'-biphenyl]-4-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-Phenylbenzaldehyde (3218-36-8) → 5-([1,1'-biphenyl]-4-yl)oxazole (1145-12-6)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In methanol; 1,2-dimethoxyethane;

DOI:10.1016/S0040-4039(99)01049-7

Reference yield:

5-(4-bromophenyl)oxazole (72571-06-3) + phenylboronic acid (98-80-6) → 5-([1,1'-biphenyl]-4-yl)oxazole (1145-12-6)

Guidance literature:

With C₁₁H₂₀N₃⁽¹⁺⁾*C₈H₁₈NO₄S₂^(1-); palladium diacetate; at 60 - 70 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201800804

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 5-([1,1'-biphenyl]-4-yl)oxazole (1145-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: C₁₁H₂₀N₃⁽¹⁺⁾*C₈H₁₈NO₄S₂^(1-); 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / 40 °C / Inert atmosphere

1.2: 60 - 70 °C / Inert atmosphere; Ionic liquid

2.1: C₁₁H₂₀N₃⁽¹⁺⁾*C₈H₁₈NO₄S₂^(1-); palladium diacetate / 4 h / 60 - 70 °C / Inert atmosphere

With C₁₁H₂₀N₃⁽¹⁺⁾*C₈H₁₈NO₄S₂^(1-); palladium diacetate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; 2.1: |Suzuki Coupling;

DOI:10.1002/ejoc.201800804

upstream raw materials:

2-Amino-1-biphenyl-4-yl-ethanone; hydrochloride

orthoformic acid triethyl ester

4-Phenylbenzaldehyde

5-(4-bromophenyl)oxazole