(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

Base Information

Chemical Name:(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal
CAS No.:1101134-52-4
Molecular Formula:C₃₁H₄₆O₃Si₂
Molecular Weight:522.875
Hs Code.:

Synonyms:(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

Suppliers and Price of (2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

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Technology Process of (2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

There total 1 articles about (2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1101134-51-3
(2S,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-yn-1-ol

: 1101134-52-4
(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tet.2010.05.028

Reference yield: 37.0%

: 1101134-52-4
(2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal

: 3536-96-7
vinylmagnesium chloride

: 1239600-13-5
(3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-4-[3-(tert-butyldiphenylsilanyloxy)propyl]oct-1-en-7-yn-3-ol

: 1101134-53-5
(3S,4S,5R)-5-(tert-butyldimethylsilanyloxy)-4-[3-(tert-butyldiphenylsilanyloxy)propyl]oct-1-en-7-yn-3-ol

Guidance literature:: (2R,3R)-3-(tert-butyldimethylsilanyloxy)-2-[3-(tert-butyldiphenylsilanyloxy)propyl]hex-5-ynal; vinylmagnesium chloride; In tetrahydrofuran; at -78 - -30 ℃; for 1.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tet.2010.05.028