methyl 2-amino>pyridine-3-carboxylate

Base Information

• Chemical Name: methyl 2-amino>pyridine-3-carboxylate
• CAS No.: 150869-56-0
• Molecular Formula: C₂₈H₃₁N₃O₃
• Molecular Weight: 457.572
• Mol file: 150869-56-0.mol

Synonyms:methyl 2-amino>pyridine-3-carboxylate

Chemical Property of methyl 2-amino>pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of methyl 2-amino>pyridine-3-carboxylate

There total 6 articles about methyl 2-amino>pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 2-chloropyridine-3-carboxylate (40134-18-7) + N-<2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl>-N-propylamine (150869-55-9) → methyl 2-amino>pyridine-3-carboxylate (150869-56-0)

Guidance literature:

With triethylamine; In toluene; for 40h; Heating;

DOI:10.1080/00397919308009863

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → methyl 2-amino>pyridine-3-carboxylate (150869-56-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) H₂ / 5percent Pt/C / 1.) MeOH, overnight, 2.) MeOH, 4 atm

2: 84 percent / Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 6 h, 2.) THF, RT, overnight

4: 88 percent / HOAc / methanol; H₂O / 2 h / Heating

5: 91 percent / Et₃N / toluene / 40 h / Heating

With hydrogen; magnesium; acetic acid; ethylene dibromide; triethylamine; platinum on activated charcoal; In methanol; dichloromethane; water; toluene;

DOI:10.1080/00397919308009863

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → methyl 2-amino>pyridine-3-carboxylate (150869-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 6 h, 2.) THF, RT, overnight

2: 88 percent / HOAc / methanol; H₂O / 2 h / Heating

3: 91 percent / Et₃N / toluene / 40 h / Heating

With magnesium; acetic acid; ethylene dibromide; triethylamine; In methanol; water; toluene;

DOI:10.1080/00397919308009863

upstream raw materials:

methyl 2-chloropyridine-3-carboxylate

N-<2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl>-N-propylamine

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4-bromo-benzaldehyde

Downstream raw materials:

methyl 2-amino>pyridine-3-carboxylate

methyl 2-biphenyl-4-yl)methyl>amino>pyridine-3-carboxylate