(+/-)-2-methylphenylglycine amide

Base Information

• Chemical Name: (+/-)-2-methylphenylglycine amide
• CAS No.: 203065-98-9
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.207
• Mol file: 203065-98-9.mol

Synonyms:(+/-)-2-methylphenylglycine amide

Chemical Property of (+/-)-2-methylphenylglycine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-methylphenylglycine amide

There total 5 articles about (+/-)-2-methylphenylglycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

α-(diphenylmethylamino)-2-methylbenzeneacetamide (1194752-74-3) → (+/-)-2-methylphenylglycine amide (203065-98-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; for 5h; under 2585.81 Torr;

Reference yield: 42.0%

DL-2-methylphenylglycine nitrile (56464-73-4) → (S)-2-amino-2-(o-tolyl)acetic acid (339274-33-8) + (+/-)-2-methylphenylglycine amide (203065-98-9)

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 12h; pH=7.62;

DOI:10.1016/S0040-4039(01)01439-3

Reference yield:

α-(diphenylmethylamino)-2-methylbenzeneacetic acid (1194752-71-0) → (+/-)-2-methylphenylglycine amide (203065-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 138 h / 20 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 5 h / 2585.81 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

DL-2-methylphenylglycine nitrile

2-methylphenyl aldehyde

α-(diphenylmethylamino)-2-methylbenzeneacetamide

α-(diphenylmethylamino)-2-methylbenzeneacetic acid

Downstream raw materials:

(S)-2-amino-2-(o-tolyl)acetic acid

D-(-)-2-methylphenylglycine