3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole

Base Information

• Chemical Name: 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole
• CAS No.: 151098-20-3
• Molecular Formula: C₁₁H₉FN₂O₃
• Molecular Weight: 236.202
• Mol file: 151098-20-3.mol

Synonyms:3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole

Chemical Property of 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl5-(4-fluorophenyl)-[1,2,4]oxadiazole-3-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

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Technology Process of 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole

There total 2 articles about 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H11FN2O4 (151097-51-7) → 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole (151098-20-3)

Guidance literature:

at 180 ℃; for 0.5h; Sealed tube; Neat (no solvent);

DOI:10.1016/j.ejmech.2012.02.002

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → 3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole (151098-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 1 h / 20 °C

2: 0.5 h / 180 °C / Sealed tube; Neat (no solvent)

With potassium carbonate; In acetone;

DOI:10.1016/j.ejmech.2012.02.002

Reference yield: 97.0%

3-(ethoxycarbonyl)-5-(4'-fluorophenyl)-1,2,4-oxadiazole (151098-20-3) → 5-(4'-fluorophenyl)-1,2,4-oxadiazole-3-carboxamide (1370025-77-6)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2012.02.002

upstream raw materials:

C₁₁H₁₁FN₂O₄

4-fluorobenzoyl chloride

Downstream raw materials:

5-(4'-fluorophenyl)-1,2,4-oxadiazole-3-carboxamide

5-(4'-(morpholin-N-yl)phenyl)-1,2,4-oxadiazole-3-carboxamide

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