methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

Base Information

Chemical Name:methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate
CAS No.:1383798-56-8
Molecular Formula:C₂₄H₂₁F₃N₂O₂
Molecular Weight:426.438
Hs Code.:

Synonyms:methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

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Chemical Property of methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

Chemical Property:

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Technology Process of methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

There total 4 articles about methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383798-54-6
methyl 6-((4'-(trifluoromethyl)biphenyl-4-yl)methyleneamino)nicotinate

: 23719-80-4
cyclopropylmagnesium bromide

: 1383798-56-8
methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

Guidance literature:: methyl 6-((4'-(trifluoromethyl)biphenyl-4-yl)methyleneamino)nicotinate; cyclopropylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 13h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1383798-56-8
methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: propan-1-ol / 0.25 h / 70 °C

1.2: 1 h / Reflux

2.1: toluene-4-sulfonic acid / toluene / 12 h / Molecular sieve; Reflux

3.1: tetrahydrofuran / 13 h / 0 - 20 °C

toluene-4-sulfonic acid; In tetrahydrofuran; propan-1-ol; toluene;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1383798-56-8
methyl 6-(cyclopropyl(4'-(trifluoromethyl)biphenyl-4-yl)methylamino)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: propan-1-ol / 0.25 h / 70 °C

1.2: 1 h / Reflux

2.1: toluene-4-sulfonic acid / toluene / 12 h / Molecular sieve; Reflux

3.1: tetrahydrofuran / 13 h / 0 - 20 °C

toluene-4-sulfonic acid; In tetrahydrofuran; propan-1-ol; toluene;