3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Base Information

Chemical Name:3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile
CAS No.:1416324-66-7
Molecular Formula:C₂₅H₂₇BrN₄O₅
Molecular Weight:543.417
Hs Code.:

Synonyms:3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

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Chemical Property of 3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

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Technology Process of 3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

There total 2 articles about 3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63069-50-1
4-cyano-2-fluoroaniline

: 1416324-66-7
3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / acetic acid / 20 °C

2: dihydrogen peroxide; acetic acid / water / 60 °C

3: potassium carbonate / acetonitrile / 18 h / 40 °C

With dihydrogen peroxide; bromine; potassium carbonate; acetic acid; In water; acetic acid; acetonitrile;

Reference yield:

: 874880-58-7
4-amino-3-bromo-5-fluorobenzonitrile

: 1416324-66-7
3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; acetic acid / water / 60 °C

2: potassium carbonate / acetonitrile / 18 h / 40 °C

With dihydrogen peroxide; potassium carbonate; acetic acid; In water; acetonitrile;

Reference yield: 45.0%

: 1416324-66-7
3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile

: 149-73-5
trimethyl orthoformate

: 1416324-67-8
4-bromo-1-((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Guidance literature:: 3-bromo-5-(((3-(3-ethoxyphenyl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)amino)-4-nitrobenzonitrile; trimethyl orthoformate; With formic acid; iron; In methanol; at 60 ℃; for 20h;

With sodium carbonate; In dichloromethane;