Technology Process of 1-(2-bromoprop-2-en-1-yl)-5-oxocyclohex-3-ene-1-carboxylic acid
There total 1 articles about 1-(2-bromoprop-2-en-1-yl)-5-oxocyclohex-3-ene-1-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-Methoxybenzoic acid;
With
ammonia; lithium;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
2-bromoallyl bromide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
hydrogenchloride;
In
water;
for 0.333333h;
Reflux;
DOI:10.1021/ol202147r
- Guidance literature:
-
Multi-step reaction with 7 steps
1: diethyl ether / 5 - 20 °C
2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 3 h / Reflux; Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere
5: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C
6: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
7: hydrogen / 96 h / 20 °C
With
copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
6: Sonogashira coupling;
DOI:10.1021/ol202147r
