isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

Base Information

Chemical Name:isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate
CAS No.:1452586-20-7
Molecular Formula:C₁₆H₁₇BrCl₃NO₅
Molecular Weight:489.578
Hs Code.:

Synonyms:isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

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Chemical Property of isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

Chemical Property:

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Technology Process of isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

There total 4 articles about isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19190-80-8,37161-74-3,40956-18-1,41603-34-3,99528-65-1,115794-66-6,115794-67-7,115794-68-8,130607-99-7
methyl trans-3-phenylglycidate

: 1452586-20-7
isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: lipase PS-C M_. miehei / hexane / 55 h / 30 °C / Enzymatic reaction

2: magnesium dibromide etherate / diethyl ether / 3.5 h / -55 - 3 °C

3: tetrahydrofuran / 2.5 h / 25 °C

With lipase PS-C M_. miehei; magnesium dibromide etherate; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1007/s11172-012-0302-4

Reference yield:

: 103-26-4,1754-62-7
Methyl cinnamate

: 1452586-20-7
isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 50 h / Reflux

2: lipase PS-C M_. miehei / hexane / 55 h / 30 °C / Enzymatic reaction

3: magnesium dibromide etherate / diethyl ether / 3.5 h / -55 - 3 °C

4: tetrahydrofuran / 2.5 h / 25 °C

With lipase PS-C M_. miehei; magnesium dibromide etherate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1007/s11172-012-0302-4

Reference yield:

: 146848-87-5
(+)-isobutyl (2S,3R)-3-phenylglycidate

: 1452586-20-7
isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium dibromide etherate / diethyl ether / 3.5 h / -55 - 3 °C

2: tetrahydrofuran / 2.5 h / 25 °C

With magnesium dibromide etherate; In tetrahydrofuran; diethyl ether;
DOI:10.1007/s11172-012-0302-4