146848-87-5

Basic information

• Product Name: (+)-isobutyl (2S,3R)-3-phenylglycidate
• Synonyms: (+)-isobutyl (2S,3R)-3-phenylglycidate
• CAS NO: 146848-87-5
• Molecular Weight: 220.268
• Mol File: 146848-87-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-isobutyl (2S,3R)-3-phenylglycidate(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-isobutyl (2S,3R)-3-phenylglycidate(146848-87-5)
• EPA Substance Registry System: (+)-isobutyl (2S,3R)-3-phenylglycidate(146848-87-5)

Safety Data

• Hazardous Substances Data: 146848-87-5(Hazardous Substances Data)

Upstream product

• 103-26-4 Methyl cinnamate 
• 78-83-1 2-methyl-propan-1-ol 
• 19190-80-8 methyl trans-3-phenylglycidate 

Downstream Products

• 79898-17-2 (2S,3R)-β-phenylglycidic acid 
• 1452586-20-7 isobutyl (2S,3R)-(+)-3-bromo-2-[N-(2,2,2-trichloroacetyl)carbamoyloxy]-3-phenylpropionate 
• 1452586-21-8 isobutyl (4S,5R)-4-phenyloxazolidin-2-one-5-carboxylate 
• 1452586-19-4 methyl (4S,5R)-3-benzoyl-4-phenyloxazolidin-2-one-5-carboxylate 
• 157240-36-3 (2R,3S)-3-phenylisoserine methyl ester 
• 144541-45-7 methyl (2S,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 
• 7309-55-9 (2S,3S)-N-benzoyl-3-phenylisoserine 
• 146848-89-7 (2S,3S)-(+)-isobutyl 3-azido-2-benzoxy-3-phenylpropionate 
• 146848-90-0 (2S,3S)-(-)-isobutyl N-benzoyl-3-phenylisoserinate 
• 146848-91-1 (4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 
• 146848-88-6 (2S,3S)-(+)-isobutyl 3-azido-2-hydroxy-3-phenylpropionate 

Relevant articles and documents

Regio- and stereoselective methods for the conversion of (2S,3R)-β-phenylglycidic acid esters to taxoids and other enantiopure (2R,3S)-phenylisoserine esters

A novel efficient method was proposed for the synthesis of enantiopure precursors of taxane-containing cytostatics, i.e., methyl esters of (2R,3S)- and (2S,3R)-N-benzoylphenylisoserine and similar taxoid esters. The method is based on the regio- and stereoselective hydrobromolysis of the corresponding trans-β-phenyl glycidate enatiomers, consecutive reactions of O-acylcarbamoylation of the obtained 3-bromohydrins, intramolecular cyclization to 4-phenyloxazolidin-2-one-5-carboxylic acid derivatives, and oxazolidinone ring opening.