2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate

Base Information

• Chemical Name: 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate
• CAS No.: 1552301-95-7
• Molecular Formula: C₂₁H₂₂O₈
• Molecular Weight: 402.401
• Mol file: 1552301-95-7.mol

Synonyms:2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate

Chemical Property of 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate

There total 4 articles about 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-(4'-hydroxyphenyl)ethyl methyl carbonate (953422-33-8) + (E)-methyl 3-(4-acetoxy-3,5-dimethoxyphenyl)acrylate (90985-69-6) → 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate (1552301-95-7)

Guidance literature:

With trifluoroacetic acid; for 5h; Temperature; Reflux;

DOI:10.1039/c3nj01180a

Reference yield:

(E)-4-acetoxy-3,5-dimethoxycinnamic acid (90985-68-5,113158-15-9) → 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate (1552301-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / 25 °C

2: trifluoroacetic acid / 5 h / Reflux

With potassium carbonate; trifluoroacetic acid; In acetone;

DOI:10.1039/c3nj01180a

Reference yield:

sinapinic acid (530-59-6,7362-37-0) → 2-[4-(4-hydroxy-3,5-dimethoxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate (1552301-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 24 h / 25 °C

2: potassium carbonate / acetone / 8 h / 25 °C

3: trifluoroacetic acid / 5 h / Reflux

With pyridine; potassium carbonate; trifluoroacetic acid; In acetone;

DOI:10.1039/c3nj01180a

upstream raw materials:

(E)-4-acetoxy-3,5-dimethoxycinnamic acid

2-(4'-hydroxyphenyl)ethyl methyl carbonate

(E)-methyl 3-(4-acetoxy-3,5-dimethoxyphenyl)acrylate

p-hydroxyphenethyl alcohol

Downstream raw materials:

3-(4-hydroxy-3,5-dimethoxyphenyl)-3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)propanoic acid