(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

Base Information

Chemical Name:(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide
CAS No.:1559021-81-6
Molecular Formula:C₂₆H₃₀Cl₂N₂O₂
Molecular Weight:473.442
Hs Code.:

Synonyms:(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

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Chemical Property of (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

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Technology Process of (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

There total 4 articles about (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1559022-11-5
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

: 1559021-81-6
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

Guidance literature:: With 4-methyl-morpholine; ammonium hydroxide; isobutyl chloroformate; In tetrahydrofuran; water; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm401753e

Reference yield:

: 1352075-22-9
(S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanal

: 1559021-81-6
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: 12 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogenchloride / acetonitrile / 1.5 h / 25 °C / Inert atmosphere

3.1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.33 h / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; isobutyl chloroformate; ammonium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; ammonium hydroxide; sodium chlorite; sodium dihydrogenphosphate; potassium hexamethylsilazane; isobutyl chloroformate; In tetrahydrofuran; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm401753e

Reference yield:

: 1352076-07-3
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanal

: 1559021-81-6
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.33 h / 20 °C / Inert atmosphere

2: 4-methyl-morpholine; isobutyl chloroformate; ammonium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; ammonium hydroxide; sodium chlorite; sodium dihydrogenphosphate; isobutyl chloroformate; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm401753e