(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

Base Information

Chemical Name:(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid
CAS No.:1559022-11-5
Molecular Formula:C₂₆H₂₉Cl₂NO₃
Molecular Weight:474.427
Hs Code.:

Synonyms:(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

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Chemical Property of (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

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Technology Process of (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

There total 3 articles about (S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1352076-07-3
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanal

: 1559022-11-5
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol; at 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/jm401753e

Reference yield:

: 1352075-22-9
(S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanal

: 1559022-11-5
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: 12 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogenchloride / acetonitrile / 1.5 h / 25 °C / Inert atmosphere

3.1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; potassium hexamethylsilazane; In tetrahydrofuran; water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm401753e

Reference yield:

: C₂₇H₃₁Cl₂NO₂

: 1559022-11-5
(S)-3-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / acetonitrile / 1.5 h / 25 °C / Inert atmosphere

2: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm401753e