diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

Base Information

• Chemical Name: diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate
• CAS No.: 1376377-43-3
• Molecular Formula: C₁₆H₂₆NO₅P
• Molecular Weight: 343.36
• Mol file: 1376377-43-3.mol

Synonyms:diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

Chemical Property of diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

There total 2 articles about diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diethyl 4-(benzyloxyamino)-4-oxobutylphosphonate (1376377-42-2) + methyl iodide (74-88-4) → diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate (1376377-43-3)

Guidance literature:

diethyl 4-(benzyloxyamino)-4-oxobutylphosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.02.031

Reference yield:

ethyl 4-(diethoxyphosphoryl)butanoate (2327-69-7) → diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate (1376377-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling

1.2: 20 °C / Inert atmosphere; Cooling

2.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2012.02.031

Reference yield:

diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate (1376377-43-3) → C12H18NO5P (1376377-45-5)

Guidance literature:

diethyl 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With water; In dichloromethane; for 0.0833333h;

DOI:10.1016/j.ejmech.2012.02.031

upstream raw materials:

diethyl 4-(benzyloxyamino)-4-oxobutylphosphonate

methyl iodide

ethyl 4-(diethoxyphosphoryl)butanoate

Downstream raw materials:

C₁₂H₁₈NO₅P

di(butyryloxymethyl) 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

di(pivaloyloxymethyl) 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

di(benzoyloxymethyl) 4-[benzyloxy(methyl)amino]-4-oxobutylphosphonate

Refernces