N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide

Base Information

• Chemical Name: N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide
• CAS No.: 168297-81-2
• Molecular Formula: C₁₃H₁₆Cl₃NO₂
• Molecular Weight: 324.635
• Mol file: 168297-81-2.mol

Synonyms:N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide

Chemical Property of N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide

There total 4 articles about N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-2-amino-3-phenyl-1,1-dimethylpropanol (170918-41-9) + trifluoroacetyl chloride (76-02-8) → N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide (168297-81-2)

Guidance literature:

With pyridine; for 94h; 1) 0 deg C, 10 min, 2) room temperature, overnight;

DOI:10.1016/S0040-4020(98)01145-4

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide (168297-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / thionyl chloride / 2 h / Heating

2: diethyl ether / 6 h / Heating

3: 69.3 g / pyridine / 12 h / 0 - 20 °C

With thionyl chloride; In pyridine; diethyl ether;

DOI:10.1021/ol0631197

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-<(S)-1-benzyl-2-hydroxy-2-methylpropyl>-2,2,2-trichloroethanamide (168297-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 6 h / Heating

2: 69.3 g / pyridine / 12 h / 0 - 20 °C

In pyridine; diethyl ether;

DOI:10.1021/ol0631197

upstream raw materials:

trifluoroacetyl chloride

(S)-2-amino-3-phenyl-1,1-dimethylpropanol

L-phenylalanine

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

C₂₄H₃₉NO₄Si

C₂₄H₃₇NO₄Si

C₁₈H₂₃NO₄

(S)-3-((E)-but-2-enoyl)-4-benzyl-5,5-dimethyloxazolidin-2-one