4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane

Base Information

• Chemical Name: 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane
• CAS No.: 1276543-46-4
• Molecular Formula: C₃₁H₄₄N₄O₄
• Molecular Weight: 536.715
• Mol file: 1276543-46-4.mol

Synonyms:4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane

Chemical Property of 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane

There total 2 articles about 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,8-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazacyclotetradecane (1264659-72-4) + propane-1,3-diol ditosylate (5469-66-9) → 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane (1276543-46-4)

Guidance literature:

With sodium carbonate; In toluene; for 144h; Reflux;

Reference yield:

1,8-bis-(benzyloxycarbonylmethyl)-4,11-diazoniatricyclo[9.3.1.1]hexadecane dibromide → 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane (1276543-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 20 °C

2: sodium carbonate / toluene / 144 h / Reflux

With sodium carbonate; sodium hydroxide; In toluene;

Reference yield:

2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) (134439-25-1) + 1,8-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazacyclotetradecane (1264659-72-4) + 4,11-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane (1276543-46-4) → 4,11-bis-(benzyloxycarbonylmethyl)-16-(4-nitrobenzyl)-1,4,8,11-tetraazabicyclo[ 6.6.3]heptadecane (1276543-55-5)

Guidance literature:

With sodium carbonate; In aq NaOH; dichloromethane; toluene;

upstream raw materials:

1,8-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazacyclotetradecane

propane-1,3-diol ditosylate

Downstream raw materials:

4,11-bis-(benzyloxycarbonylmethyl)-16-(4-nitrobenzyl)-1,4,8,11-tetraazabicyclo[ 6.6.3]heptadecane

C₄₄H₇₁N₁₃O₁₁