2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)

Base Information

• Chemical Name: 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)
• CAS No.: 134439-25-1
• Molecular Formula: C₂₄H₂₅NO₈S₂
• Molecular Weight: 519.596
• Mol file: 134439-25-1.mol

Synonyms:2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)

Chemical Property of 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate)

There total 3 articles about 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-[(4-nitrophenyl)methyl]propan-1,3-diol (73344-98-6) + p-toluenesulfonyl chloride (98-59-9) → 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) (134439-25-1)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 10h;

Reference yield:

diethyl 2-(4-nitrobenzyl)malonate (7598-70-1) → 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) (134439-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 16 h / Reflux

2: pyridine / 10 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; In ethanol;

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) (134439-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 1 h / 45 °C

2: sodium tetrahydroborate / ethanol / 16 h / Reflux

3: pyridine / 10 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; potassium carbonate; In ethanol; acetone;

upstream raw materials:

diethyl 2-(4-nitrobenzyl)malonate

2-[(4-nitrophenyl)methyl]propan-1,3-diol

p-toluenesulfonyl chloride

1-bromomethyl-4-nitro-benzene

Downstream raw materials:

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

4,11-bis-(benzyloxycarbonylmethyl)-16-(4-nitrobenzyl)-1,4,8,11-tetraazabicyclo[ 6.6.3]heptadecane

4,11-N,N'-bis(carboxymethyl)-16-(4-isothiocyanatobenzyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane