1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

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Chemical Name:1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea
CAS No.:1321451-84-6
Molecular Formula:C₂₇H₂₅F₂N₇O₃
Molecular Weight:533.537
Hs Code.:

Synonyms:1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

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Chemical Property of 1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

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Technology Process of 1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

There total 11 articles about 1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1160825-67-1
7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

: 1012879-53-6
3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazole-5-carboxylic acid

: 1321451-84-6
1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: 3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one; In N,N-dimethyl-formamide; at 110 ℃; for 1h;

Reference yield:

: 1163720-60-2
4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-3-nitro-2-aminopyridine

: 1321451-84-6
1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

2.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / water / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

4.2: 18 h / 0 - 20 °C

5.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

6.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

6.2: 1 h / 110 °C

With pyridine; diphenyl phosphoryl azide; hydrogen; sodium ethanolate; sodium hydride; triethylamine; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1321451-84-6
1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C

3.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

4.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

5.1: trifluoroacetic acid / water / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

6.2: 18 h / 0 - 20 °C

7.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

8.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

8.2: 1 h / 110 °C

With pyridine; diphenyl phosphoryl azide; hydrogen; sodium ethanolate; sodium hydride; triethylamine; trifluoroacetic acid; indium(III) chloride; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; mineral oil;