7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Base Information

Chemical Name:7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
CAS No.:1160825-67-1
Molecular Formula:C₁₃H₁₁FN₄O₂
Molecular Weight:274.254
Hs Code.:

Synonyms:7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

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Chemical Property of 7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

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Technology Process of 7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

There total 7 articles about 7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1160825-93-3
ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

: 1160825-67-1
7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: With sodium ethanolate; In ethanol; for 1h; Microwave irradiation;
DOI:10.1021/jm900242c

Reference yield:

: 1163720-60-2
4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-3-nitro-2-aminopyridine

: 1160825-67-1
7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

2.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / water / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

4.2: 18 h / 0 - 20 °C

5.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

With pyridine; hydrogen; sodium ethanolate; sodium hydride; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; mineral oil;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1160825-67-1
7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C

3.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

4.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

5.1: trifluoroacetic acid / water / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

6.2: 18 h / 0 - 20 °C

7.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

With pyridine; hydrogen; sodium ethanolate; sodium hydride; trifluoroacetic acid; indium(III) chloride; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; ethyl acetate; mineral oil;