dicesium methotrexate

Base Information

• Chemical Name: dicesium methotrexate
• CAS No.: 86669-44-5
• Molecular Formula: C₂₀H₂₀N₈O₅*2Cs
• Molecular Weight: 718.24

Synonyms:dicesium methotrexate

Chemical Property of dicesium methotrexate

Chemical Property:

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Technology Process of dicesium methotrexate

There total 1 articles about dicesium methotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid (59-05-2) → dicesium methotrexate (86669-44-5)

Guidance literature:

With cesium bicarbonate; In water; for 4h;

Reference yield: 70.0%

benzyl chloride (100-44-7) + dicesium methotrexate (86669-44-5) → dibenzyl methotrexate (60219-06-9)

Guidance literature:

In dimethyl sulfoxide; for 20h; Ambient temperature;

DOI:10.1021/jm00364a017

Reference yield: 31.0%

nicotinyl chloride (3099-31-8) + dicesium methotrexate (86669-44-5) → (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid dipyridin-3-ylmethyl ester (86669-37-6)

Guidance literature:

In dimethyl sulfoxide; for 20h; Ambient temperature;

DOI:10.1021/jm00364a017

upstream raw materials:

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Downstream raw materials:

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid dipyridin-3-ylmethyl ester

dibenzyl methotrexate

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