(S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester
• CAS No.: 907217-47-4
• Molecular Formula: C₂₆H₄₂O₃S₂
• Molecular Weight: 466.75
• Mol file: 907217-47-4.mol

Synonyms:(S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester

Chemical Property of (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester

There total 4 articles about (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(S)-1-((S)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-2-[(R)-1-hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octan-1-one (907217-46-3) + benzyl alcohol (100-51-6,185532-71-2) → (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester (907217-47-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 46h;

DOI:10.1021/jo060844m

Reference yield:

1-((S)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-octan-1-one (907217-45-2) → (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester (907217-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / TMEDA / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / DMAP / CH₂Cl₂ / 46 h / 20 °C

With dmap; N,N,N,N,-tetramethylethylenediamine; In dichloromethane;

DOI:10.1021/jo060844m

Reference yield:

(2-Pentyl-[1,3]dithian-2-yl)-acetaldehyde (38293-03-7) → (S)-2-[(R)-1-Hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octanoic acid benzyl ester (907217-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / TMEDA / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / DMAP / CH₂Cl₂ / 46 h / 20 °C

With dmap; N,N,N,N,-tetramethylethylenediamine; In dichloromethane;

DOI:10.1021/jo060844m

upstream raw materials:

(S)-1-((S)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-2-[(R)-1-hydroxy-2-(2-pentyl-[1,3]dithian-2-yl)-ethyl]-octan-1-one

benzyl alcohol

1-((S)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-octan-1-one

(2-Pentyl-[1,3]dithian-2-yl)-acetaldehyde

Downstream raw materials:

valilactone

(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

(2S,3R,5S)-2-Hexyl-3-hydroxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

(2S,3R,5S)-2-Hexyl-3,5-dihydroxy-decanoic acid benzyl ester