(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

Base Information

Chemical Name:(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester
CAS No.:907217-51-0
Molecular Formula:C₃₃H₆₀O₆SSi
Molecular Weight:612.987
Hs Code.:

Synonyms:(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

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Chemical Property of (2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

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Technology Process of (2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

There total 8 articles about (2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 907217-50-9
(2S,3R,5S)-2-Hexyl-3-hydroxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

: 124-63-0
methanesulfonyl chloride

: 907217-51-0
(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo060844m

Reference yield:

: 907217-45-2
1-((S)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-octan-1-one

: 907217-51-0
(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / TMEDA / CH₂Cl₂ / 2 h / 0 °C

2: 75 percent / DMAP / CH₂Cl₂ / 46 h / 20 °C

3: 87 percent / NaHCO₃; I₂ / acetone; H₂O / 15 h / 0 °C

4: 97 percent / Me₄NBH(OAc)3 / acetonitrile; acetic acid / 3 h / -15 °C

5: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

6: 87 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 °C

With 2,6-dimethylpyridine; dmap; N,N,N,N,-tetramethylethylenediamine; iodine; sodium hydrogencarbonate; triethylamine; tetramethylammonium triacetoxyborohydride; In dichloromethane; water; acetic acid; acetone; acetonitrile;
DOI:10.1021/jo060844m

Reference yield:

: 907217-48-5
(2S,3R)-2-Hexyl-3-hydroxy-5-oxo-decanoic acid benzyl ester

: 907217-51-0
(2S,3R,5S)-2-Hexyl-3-methanesulfonyloxy-5-triisopropylsilanyloxy-decanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Me₄NBH(OAc)3 / acetonitrile; acetic acid / 3 h / -15 °C

2: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

3: 87 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 °C

With 2,6-dimethylpyridine; triethylamine; tetramethylammonium triacetoxyborohydride; In dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/jo060844m