(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

Base Information

Chemical Name:(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide
CAS No.:1353054-49-5
Molecular Formula:C₄₄H₇₁N₃O₃
Molecular Weight:690.066
Hs Code.:

Synonyms:(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

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Technology Process of (S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

There total 9 articles about (S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1353054-48-4
(S)-tert-butyl 1-(hexadecylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)-1-oxopropan-2-ylcarbamate

: 1353054-49-5
(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Darkness;
DOI:10.1016/j.bmc.2011.10.043

Reference yield:

: 111-81-9
Methyl 10-undecenoate

: 1353054-49-5
(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 22 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 20 °C

2.2: pH 1

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

3.2: 2.5 h / 20 °C / Darkness

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

4.2: 5 h / 20 °C / Darkness

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Darkness

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.043

Reference yield:

: 1353054-47-3
(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

: 1353054-49-5
(S)-N-(2-amino-3-(hexadecylamino)-3-oxopropyl)-11-(4-(4-methylbenzoyl)phenyl)undecanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

1.2: 5 h / 20 °C / Darkness

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Darkness

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2011.10.043