(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid
CAS No.:1353054-47-3
Molecular Formula:C₃₃H₄₆N₂O₆
Molecular Weight:566.738
Hs Code.:

Synonyms:(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

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Chemical Property of (S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

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Technology Process of (S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

There total 6 articles about (S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 76387-70-7
(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

: 128596-03-2
11-(4-(4-methylbenzoyl)phenyl)undecanoic acid

: 1353054-47-3
(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

Guidance literature:: 11-(4-(4-methylbenzoyl)phenyl)undecanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid; In methanol; dichloromethane; at 20 ℃; for 2.5h; Darkness;
DOI:10.1016/j.bmc.2011.10.043

Reference yield:

: 111-81-9
Methyl 10-undecenoate

: 1353054-47-3
(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 22 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 20 °C

2.2: pH 1

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

3.2: 2.5 h / 20 °C / Darkness

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 1.2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.043

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 1353054-47-3
(S)-2-(tert-butoxycarbonylamino)-3-(11-(4-(4-methylbenzoyl)phenyl)undecanamido)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / 2 h / Reflux

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 22 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / ethanol / 20 °C

3.2: pH 1

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h

4.2: 2.5 h / 20 °C / Darkness

With aluminum (III) chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; 1.1: Friedel Crafts reaction / 2.2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.10.043