4-(methoxycarbonyl)benzyl chloroformate

Base Information

• Chemical Name: 4-(methoxycarbonyl)benzyl chloroformate
• CAS No.: 373638-45-0
• Molecular Formula: C₁₀H₉ClO₄
• Molecular Weight: 228.632
• Mol file: 373638-45-0.mol

Synonyms:4-(methoxycarbonyl)benzyl chloroformate

Chemical Property of 4-(methoxycarbonyl)benzyl chloroformate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(methoxycarbonyl)benzyl chloroformate

There total 2 articles about 4-(methoxycarbonyl)benzyl chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

bis(trichloromethyl) carbonate (32315-10-9) + 4-(methoxycarbonyl)benzyl alcohol (6908-41-4,58590-49-1) → 4-(methoxycarbonyl)benzyl chloroformate (373638-45-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c9ob00628a

Reference yield:

phosgene (75-44-5) + 4-(methoxycarbonyl)benzyl alcohol (6908-41-4,58590-49-1) → 4-(methoxycarbonyl)benzyl chloroformate (373638-45-0)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2010.10.033

Reference yield: 95.0%

4-iodobenzonitrile (3058-39-7) + 4-(methoxycarbonyl)benzyl chloroformate (373638-45-0) → methyl 4-(4-cyanobenzyl)benzoate (162554-06-5)

Guidance literature:

With bis(acetylacetonate)nickel(II); 4,4'-Dimethoxy-2,2'-bipyridin; magnesium bromide; zinc; In N,N-dimethyl acetamide; at 40 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9ob00628a

upstream raw materials:

phosgene

4-(methoxycarbonyl)benzyl alcohol

bis(trichloromethyl) carbonate

Downstream raw materials:

C₂₃H₃₂N₂O₆

methyl 4-(4-cyanobenzyl)benzoate