C₃₇H₄₆O₅

Base Information

• Chemical Name: C₃₇H₄₆O₅
• CAS No.: 1013657-42-5
• Molecular Formula: C₃₇H₄₆O₅
• Molecular Weight: 570.769
• Mol file: 1013657-42-5.mol

Synonyms:C₃₇H₄₆O₅

Chemical Property of C₃₇H₄₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₆O₅

There total 8 articles about C₃₇H₄₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

((1S,2S,3S)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)cyclobutane-1,2-diyl)dimethanol (1013657-41-4) + benzoyl chloride (98-88-4) → C37H46O5 (1013657-42-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In pyridine; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo202261z

Reference yield:

(R,Z)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)prop-2-en-1-ol (1357378-25-6) → C37H46O5 (1013657-42-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

2.1: zinc/copper couple / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium chloride / methanol; diethyl ether / 0.17 h / Inert atmosphere; Reflux

4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1.42 h / -35 - 20 °C / Inert atmosphere

4.2: 3.5 h / 20 °C / Reflux; Inert atmosphere

5.1: dichloromethane; water / 1 h / Inert atmosphere

6.1: sodium methylate / methanol / 25 h / 20 °C / Inert atmosphere

7.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

9.1: tetra-(n-butyl)ammonium iodide / pyridine / 0.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; zinc/copper couple; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; ammonium chloride; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo202261z

Reference yield:

(2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanone (1013657-37-8) → C37H46O5 (1013657-42-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1.42 h / -35 - 20 °C / Inert atmosphere

1.2: 3.5 h / 20 °C / Reflux; Inert atmosphere

2.1: dichloromethane; water / 1 h / Inert atmosphere

3.1: sodium methylate / methanol / 25 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

6.1: tetra-(n-butyl)ammonium iodide / pyridine / 0.5 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water; toluene;

DOI:10.1021/jo202261z

upstream raw materials:

((1S,2S,3S)-3-(1-(2,4,6-triisopropylphenyl)ethoxy)cyclobutane-1,2-diyl)dimethanol

benzoyl chloride

(2S,3S)-3-((R)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-((triisopropylsilyloxy)methyl)cyclobutanone

(R,Z)-triisopropyl(3-(1-(2,4,6-triisopropylphenyl)ethoxy)allyloxy)silane

Downstream raw materials:

<(1S)-(1α,2β,3β)>-3-Hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

lobucavir