5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole
CAS No.:1443650-84-7
Molecular Formula:C₂₄H₄₀N₄O₃SSi
Molecular Weight:492.758
Hs Code.:

Synonyms:5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

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Chemical Property of 5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

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Technology Process of 5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

There total 9 articles about 5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1443651-28-2
5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylthio)-1-phenyl-1H-tetrazole

: 1443650-84-7
5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With ammonium molybdate; dihydrogen peroxide; In ethanol; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/chem.201204545

Reference yield:

: 1228675-56-6
(((2R,3R)-1-(benzyloxy)-3-methylpent-4-en-2-yl)oxy)(tert-butyl)dimethylsilane

: 1443650-84-7
5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: palladium hydroxide, 20 wt% on carbon; hydrogen / ethanol / 2 h / 20 °C / 759.83 Torr

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4: ammonium molybdate; dihydrogen peroxide / ethanol / 18 h / 0 - 20 °C / Inert atmosphere

With ammonium molybdate; palladium hydroxide, 20 wt% on carbon; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane; 2: |Dess-Martin Oxidation / 3: |Julia-Kocienski Olefination;
DOI:10.1002/chem.201204545

Reference yield:

: 1443650-77-8
C₁₂H₂₈O₂Si

: 1443650-84-7
5-((2S,6R,7R,E)-6-(tert-butyldimethylsilyloxy)-2,7-dimethylnon-4-enylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: ammonium molybdate; dihydrogen peroxide / ethanol / 18 h / 0 - 20 °C / Inert atmosphere

With ammonium molybdate; dihydrogen peroxide; sodium hexamethyldisilazane; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane; 1: |Dess-Martin Oxidation / 2: |Julia-Kocienski Olefination;
DOI:10.1002/chem.201204545