(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

Base Information

Chemical Name:(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt
CAS No.:1403884-57-0
Molecular Formula:C₆H₁₄N₄O₂*C₂₃H₁₆BrF₅N₂O₇
Molecular Weight:781.488
Hs Code.:

Synonyms:(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

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Chemical Property of (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

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Technology Process of (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

There total 15 articles about (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 74-79-3,25212-18-4
L-arginine

: 1403882-59-6
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

: 1403884-57-0
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403884-57-0
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2 h / 130 °C

2.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide; acetic acid / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7.1: potassium carbonate / methanol / 1 h / 20 °C

8.1: CHIRALPAK_.(R). AD-H / hexane; ethanol; methanol / 25 °C / Resolution of racemate

9.1: pyridine / dmap / 16 h / 20 °C

9.2: 0 °C / pH 4 - 5

10.1: dichloromethane; methanol / 1 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; dmap; In methanol; tetrachloromethane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403884-57-0
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid L-arginine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; acetic acid / 20 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C

5.1: CHIRALPAK_.(R). AD-H / hexane; ethanol; methanol / 25 °C / Resolution of racemate

6.1: pyridine / dmap / 16 h / 20 °C

6.2: 0 °C / pH 4 - 5

7.1: dichloromethane; methanol / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; dmap; In methanol; tetrachloromethane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;