(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

Base Information

Chemical Name:(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid
CAS No.:1403882-59-6
Molecular Formula:C₂₃H₁₆BrF₅N₂O₇
Molecular Weight:607.285
Hs Code.:

Synonyms:(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

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Chemical Property of (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

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Technology Process of (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

There total 13 articles about (R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 108-30-5
succinic acid anhydride

: 1403880-93-2
(R)-3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

: 1403882-59-6
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

Guidance literature:: succinic acid anhydride; (R)-3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide; With pyridine; dmap; at 20 ℃; for 16h;

With hydrogenchloride; In water; at 0 ℃; pH=4 - 5;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403882-59-6
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 2 h / 130 °C

2.1: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-Bromosuccinimide; acetic acid / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7.1: potassium carbonate / methanol / 1 h / 20 °C

8.1: CHIRALPAK_.(R). AD-H / hexane; ethanol; methanol / 25 °C / Resolution of racemate

9.1: pyridine / dmap / 16 h / 20 °C

9.2: 0 °C / pH 4 - 5

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; dmap; In methanol; tetrachloromethane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403880-90-9
2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethyl acetate

: 1403882-59-6
(R)-4-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 1 h / 20 °C

2.1: CHIRALPAK_.(R). AD-H / hexane; ethanol; methanol / 25 °C / Resolution of racemate

3.1: pyridine / dmap / 16 h / 20 °C

3.2: 0 °C / pH 4 - 5

With pyridine; potassium carbonate; dmap; In methanol; ethanol; hexane;