N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

Base Information

Chemical Name:N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide
CAS No.:952493-92-4
Molecular Formula:C₁₈H₂₄IN₃O₂
Molecular Weight:441.312
Hs Code.:

Synonyms:N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

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Chemical Property of N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

Chemical Property:

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Technology Process of N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

There total 4 articles about N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-64-1
acetone

: 952493-92-4
N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

Guidance literature:: N,N-diethyl-2-(5-iodoimidazol-1-ylmethyl)benzamide; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; for 0.75h;

acetone; In tetrahydrofuran; hexanes; for 1h;

With water; sodium hydrogencarbonate; acetic acid; more than 3 stages;

Reference yield:

: 952493-88-8
N,N-diethyl-2-(5-iodoimidazol-1-ylmethyl)benzamide

: 67-64-1
acetone

: 952493-92-4
N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

Guidance literature:: N,N-diethyl-2-(5-iodoimidazol-1-ylmethyl)benzamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

acetone; With acetic acid; In tetrahydrofuran; water; for 1h;
DOI:10.1021/acs.jmedchem.5b00407

Reference yield:

: 103258-38-4
N,N-diethyl-2-(hydroxymethyl)benzamide

: 952493-92-4
N,N-diethyl-2-[2-hydroxy-1-(5-iodoimidazol-1-yl)-2-methylpropyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

2.2: 1 h

With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.5b00407