N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

Base Information

Chemical Name:N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide
CAS No.:1059735-13-5
Molecular Formula:C₂₈H₂₃N₅O
Molecular Weight:445.524
Hs Code.:

Synonyms:N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

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Chemical Property of N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

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Technology Process of N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

There total 7 articles about N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1059735-38-4
2-chloro-4-phenylpyrido[2,3-d]pyrimidine

: 787-93-9
ameltolide

: 1059735-13-5
N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 61h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b03214

Reference yield:

: C₂₀H₁₄N₄O₂

: 87-62-7
2,6-dimethylaniline

: 1059735-13-5
N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 98-80-6
phenylboronic acid

: 1059735-13-5
N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: platinum(IV) oxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 18 h / 40 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 61 h / 120 °C / Inert atmosphere

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In water; butan-1-ol; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.orglett.7b03214