1059735-38-4

Basic information

• Product Name: 2-chloro-4-phenylpyrido[2,3-d]pyrimidine
• Synonyms: 2-chloro-4-phenylpyrido[2,3-d]pyrimidine
• CAS NO: 1059735-38-4
• Molecular Weight: 241.68
• Mol File: 1059735-38-4.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-phenylpyrido[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-phenylpyrido[2,3-d]pyrimidine(1059735-38-4)
• EPA Substance Registry System: 2-chloro-4-phenylpyrido[2,3-d]pyrimidine(1059735-38-4)

Safety Data

• Hazardous Substances Data: 1059735-38-4(Hazardous Substances Data)

Upstream product

• 126728-20-9 2,4-dichloropyrido[2,3-d]pyrimidine 
• 98-80-6 phenylboronic acid 
• 100-58-3 phenylmagnesium bromide 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 
• 28721-30-4 C₁₃H₉N₃O 

Downstream Products

• 1381870-57-0 4-phenyl-2-(4-methoxyphenyl)pyrido[2,3-d]pyrimidine 
• 1059735-13-5 N-(2,6-dimethylphenyl)-4-((4-phenylpyrido[2,3-d]pyrimidin-2-yl)amino)benzamide 

Relevant articles and documents

Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware

Functionalized bicyclic amino-azaheterocycles are rapidly accessed in a one-pot cross-coupling/reduction sequence enabled by the use of COware. Incompatible reagents are physically separated in a single reaction vessel to effect two chemoselective transformations - Suzuki-Miyaura cross-coupling and heteroarene reduction. The developed method allows access to novel heterocyclic templates, including semisaturated Hedgehog and dual PI3K/mTOR inhibitors, which show enhanced physicochemical properties compared to their unsaturated counterparts.

INDOLOACRIDINE-CONTAINING DERIVATIVE, PREPARATION PROCESS AND USE THEREOF, AND ORGANIC LUMINESCENT DEVICE

The disclosure provides an indoloacridine-containing derivative represented by formula (I), wherein A is a group represented by formula (II), and wherein X, Y, Z and W represent a carbon atom or a nitrogen atom, and at least one of W, X, Y and Z represent a nitrogen atom; R represents a phenyl group, a biphenylyl group, a naphthyl group or a phenanthryl group. The disclosure further provides a process for preparing the compound. The disclosure further provides an organic electroluminescent device comprising the compound. This compound can be used as a phosphorescence host material, a hole-injecting material or a hole-transporting material in an organic electroluminescent device.

Convenient synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines via regioselective palladium-catalyzed reactions

A novel and effective route for the synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines III is reported starting from the corresponding 2,4-dichloropyridopyrimidine 1 through regioselective functionalization palladium-catalyzed C-C coupling reactions, by two successive palladium-catalyzed reactions involving an original regioselective chlorine discrimination. Alternatively, type III compounds were elaborated from 2 by C-2 chlorine further displacement of the C-4 isopropylsulfanyl group, which acted as a temporary C-4 protecting group. Further Suzuki-Miyaura cross-coupling reactions led to C-2 and C-4 disubstituted compounds.

INHIBITORS OF THE HEDGEHOG PATHWAY

The present invention is directed to a compound of Formula (I) or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula (I) to treat cancer.