L 651580

Base Information

• Chemical Name: L 651580
• CAS No.: 103335-44-0
• Molecular Formula: C₂₁H₃₁NO₃
• Molecular Weight: 345.482
• Mol file: 103335-44-0.mol

Synonyms:4-Azaandrost-1-ene-17-carboxylicacid, 4-methyl-3-oxo-, methyl ester, (5a,17b)-; 1H-Indeno[5,4-f]quinoline-7-carboxylic acid,1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4a,6a-trimethyl-2-oxo-,methyl ester, [4aR-(4aa,4bb,6aa,7a,9ab,9ba,11ab)]-; L 651580

Chemical Property of L 651580

Chemical Property:

• Vapor Pressure: 4.25E-09mmHg at 25°C
• Boiling Point: 472.5°C at 760 mmHg
• Flash Point: 239.6°C
• PSA: 46.61000
• Density: 1.105g/cm³
• LogP: 3.35290

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

1H-Indeno[5,4-f]quinoline-7-carboxylicacid,2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4a,6a-trimethyl-2-oxo-,methylester,(4aR,4bS,6aS,7S,9aS,9bS,11aR)- 99.30% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L 651580

There total 3 articles about L 651580 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate (103335-41-7) + methyl iodide (74-88-4) → Methyl 4-methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide (103335-44-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 24 deg C, 15 min, 2.) DMF, 50 deg C, 2 h;

DOI:10.1021/jm00161a028

Reference yield:

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate (103335-41-7) + dimethyl sulfate (77-78-1) → Methyl 4-methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide (103335-44-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 - 60 ℃; for 16h;

Reference yield:

→ Methyl 4-methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide (103335-44-0)

Guidance literature:

upstream raw materials:

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate

methyl iodide

dimethyl sulfate