N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide

Base Information

• Chemical Name: N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide
• CAS No.: 934420-98-1
• Molecular Formula: C₃₂H₄₇N₃O₅S
• Molecular Weight: 585.808

Synonyms:N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide

Chemical Property of N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide

Chemical Property:

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Technology Process of N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide

There total 2 articles about N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-cyclohexyl-oxazolidine (934420-84-5) + 1,1,3,3-tetramethylbutane isonitrile (14542-93-9) + 2-(toluene-4-sulfonylamino)-benzoic acid (6311-23-5) → N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide (934420-98-1)

Guidance literature:

With 3 A molecular sieve; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo062626z

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide (934420-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / diethyl ether / 1 h / 20 °C

2: 35 percent / molecular sieves 3 Angstroem / methanol / 24 h / 20 °C

With 3 A molecular sieve; 4 A molecular sieve; In methanol; diethyl ether; 2: Ugi reaction;

DOI:10.1021/jo062626z

Reference yield: 82.0%

N-[cyclohexyl-(1,1,3,3-tetramethyl-butylcarbamoyl)-methyl]-N-(2-hydroxy-ethyl)-2-(toluene-4-sulfonylamino)-benzamide (934420-98-1) → 2-cyclohexyl-2-[5-oxo-1-(toluene-4-sulfonyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-N-(1,1,3,3-tetramethyl-butyl)-acetamide

Guidance literature:

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo062626z

upstream raw materials:

2-cyclohexyl-oxazolidine

1,1,3,3-tetramethylbutane isonitrile

2-(toluene-4-sulfonylamino)-benzoic acid

cyclohexanecarbaldehyde

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