3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

Base Information

Chemical Name:3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide
CAS No.:224313-73-9
Molecular Formula:C₁₄H₁₇NO₅S₂
Molecular Weight:343.425
Hs Code.:

Synonyms:3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

Chemical Property:

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Technology Process of 3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

There total 9 articles about 3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 107-30-2
chloromethyl methyl ether

: 224313-55-7
3-(hydroxymethyl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide

: 224313-73-9
3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1002/jhet.5570360111

Reference yield:

: 71637-34-8
3-hydroxymethyl-thiophene

: 224313-73-9
3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, reflux, 30 min, 2.) THF, reflux, 1 h

2: 1.) n-BuLi, 2.) SO₂, 3.) N-chlorosuccinimide

3: 57 percent / tetrahydrofuran / 0.08 h / 0 °C

4: 51 percent / 1.5 M ethanolic HCl / 1 h / 70 °C

5: 40 percent / (i-Pr)2NEt / CH₂Cl₂ / 18 h / Ambient temperature

With hydrogenchloride; N-chloro-succinimide; n-butyllithium; sulfur dioxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570360111

Reference yield:

: 13250-82-3
2-(thiophen-3-yl)-1,3-dioxolane

: 224313-73-9
3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLI, 2.) SO₂, 3.) N-chlorosuccinimide

2: tetrahydrofuran / 18 h / Ambient temperature

3: aq. HCl / tetrahydrofuran / 16 h / Ambient temperature

4: 82 percent / NaBH₄ / ethanol / 5 h / Ambient temperature

5: 40 percent / (i-Pr)2NEt / CH₂Cl₂ / 18 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; sulfur dioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/jhet.5570360111