13250-82-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Thiophenecarboxaldehyde ethylene acetal is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Thiophenecarboxaldehyde ethylene acetal serves as a vital building block for the production of different agrochemicals. Its role in this industry is instrumental in developing effective solutions for pest control and crop protection.
Used in Fragrance Industry:
3-Thiophenecarboxaldehyde ethylene acetal is employed as a precursor in the creation of various fragrances. Its distinctive odor makes it a valuable component in the formulation of scents for perfumes, cosmetics, and other fragranced products.
Used as a Flavoring Agent in the Food Industry:
3-Thiophenecarboxaldehyde ethylene acetal is also used in the food industry as a flavoring agent. Its strong odor lends itself to enhancing the taste profiles of various food products, contributing to the development of unique and appealing flavors.
Safety Precautions:
It is important to handle 3-Thiophenecarboxaldehyde ethylene acetal with care due to its potential harmful effects if ingested or inhaled. Additionally, it can cause skin and eye irritation, necessitating proper protective measures during its use and storage.

InChI:InChI=1/C7H8O2S/c1-4-10-5-6(1)7-8-2-3-9-7/h1,4-5,7H,2-3H2

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 616-44-4 3-Methylthiophene 
• 34846-44-1 3-Bromomethylthiophene 
• 107-21-1 ethylene glycol 

Downstream Products

• 13250-83-4 2,3-Thiophenedicarbaldehyde 3-(Ethylene acetal) 
• 103011-38-7 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride 
• 167770-26-5 2-[2-[(2-nitrophenyl)methyl]-thien-3-yl]-1,3-dioxolane 
• 14756-75-3 thieno<2,3-b>thiophene-2-carboxylic acid 
• 1431866-23-7 C₁₈H₂₀N₂OS₂ 
• 1431866-21-5 C₁₇H₁₈N₂OS₂ 
• 1431866-20-4 C₁₇H₁₈N₂OS₂ 
• 1431866-19-1 C₁₉H₂₂N₂O₂S₂ 
• 1431866-17-9 C₁₉H₂₂N₂OS₂ 
• 1431866-16-8 C₁₉H₂₂N₂O₂S₂ 
• 1431866-10-2 C₁₈H₂₀N₂OS₂ 
• 84815-20-3 2-methyl-3-thiophenecarboxaldehyde 
• 128620-92-8 5-<<(methoxyethyl)<(methoxyethoxy)ethyl>amino>methyl>thieno<2,3-b>thiophene-2-sulfonamide 
• 133445-74-6 5-[(2-Methanesulfonyl-ethylamino)-methyl]-thieno[2,3-b]thiophene-2-sulfonic acid amide 

Relevant academic research and scientific papers

Small isomeric push-pull chromophores based on thienothiophenes with tunable optical (non)linearities

Fourteen new D-π-A push-pull chromophores based on two isomeric thienothiophene donors and seven acceptors of various electronic natures have been designed and conveniently synthesized. In contrast to known thienothiophene push-pull molecules, the prepared small chromophores proved to be organic materials with easily tunable thermal, electrochemical and (non)linear optical properties. It has also been shown that small structural variation may result in significantly improved/varied fundamental properties. Very detailed structure-property relationships were elucidated within the systematically developed series of push-pull molecules, which may serve as a useful guide in designing new D-π-A molecules based on fused thiophene scaffolds.

D/A cruciform bithiophene chromophores as potential molecular scaffolds for optoelectronic applications

Thiophene-based molecular semiconductors are of high interest in the development of optoelectronics devices and are extensively used. So far, structural variations have been widely performed on linear molecular push-pull in order to optimize their photoph

Method for preparing thiophene borate

The invention relates to a method for preparing thiophene borate. The method comprises the following steps: (1) mixing 3-thiophenecarboxaldehyde, p-toluene sulfonic acid monohydrate, ethylene glycol and methylbenzene, performing a backflow dehydration reaction, and performing extraction, drying, filtration, spinning drying and elution in sequence so as to obtain 2-(3-thienyl)-1,3-dioxolame; (2) performing nitrogen displacement on 2-(3-thienyl)-1,3-dioxolame, adding anhydrous tetrahydrofuran, dropping n-butyllithium and isopropoxy boric acid pinacol ester to implement a reaction, performing a quenching reaction, extraction, drying, spinning drying, adding dichloromethane to completely dissolve the components, further adding petroleum ether till no solid is separated out, finally performingspinning evaporation to remove dichloromethane and residual petroleum ether, and performing freezing and suction extraction when a 2-boric acid pinacol diester-3-(1,3-dioxolame)-yl thiophene solid isseparated out, thereby obtaining a white solid, namely 2-boric acid pinacol diester-3-(1,3-dioxolame)-yl thiophene. The method provided by the invention is simple, high in yield and easy in industrialproduction.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Outside rules inside: The role of electron-active substituents in thiophene-based heterophenoquinones

The biradicaloid vs. quinoidal character of the ground state of thiophene-based heterophenoquinones bearing donor or acceptor groups is investigated. Keeping the conjugation length fixed, namely, the 5,5′-bis(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadiene-1-y

The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles

A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles. The Royal Society of Chemistry 2013.

THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR

The present invention provides a novel thiazole derivative useful as a VAP-1 inhibitor, a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

Synthesis of the fused heterobicycles 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine

Three new pyridyl thienopyridines, 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine, have been synthesized, each through a different synthetic sequence. Overall yields ranged from 8% to 32%. Georg Thieme Verlag Stuttgart.

FAB I INHIBITORS

Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

FIBROSIS INHIBITOR

Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2):(1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms:(2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.