(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

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Chemical Name:(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one
CAS No.:1181581-52-1
Molecular Formula:C₂₁H₂₆N₂O₃
Molecular Weight:354.449
Hs Code.:

Synonyms:(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

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Chemical Property of (RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

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Technology Process of (RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

There total 3 articles about (RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 4664-01-1
3,4-pyridinedicarboximide

: 851436-85-6
1-bromo-3-(octyloxy)benzene

: 1181581-52-1
(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

: C₂₁H₂₆N₂O₃

Guidance literature:: 1-bromo-3-(octyloxy)benzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 - -50 ℃; Inert atmosphere;

3,4-pyridinedicarboximide; In tetrahydrofuran; at -78 - -50 ℃;

Reference yield:

: 591-20-8
3-Bromophenol

: 1181581-52-1
(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

: C₂₁H₂₆N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -50 - -40 °C / Inert atmosphere

2.2: 1 h / -50 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.017

Reference yield:

: 629-27-6
1-Iodooctane

: 591-20-8
3-Bromophenol

: 1181581-52-1
(RS)-1-hydroxy-1-[3-(octyloxy)phenyl]-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

: C₂₁H₂₆N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / -78 - -50 °C / Inert atmosphere

2.2: -78 - -50 °C

With tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;