4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

Base Information

Chemical Name:4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile
CAS No.:1360628-99-4
Molecular Formula:C₂₄H₁₉FN₄O₂
Molecular Weight:414.439
Hs Code.:

Synonyms:4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

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Chemical Property of 4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

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Technology Process of 4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

There total 2 articles about 4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360628-98-3
4-(6-benzyloxy-7-methoxy-3-nitro-quinolin-4-yl-amino)-3-fluorobenzonitrile

: 1360628-99-4
4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; at 70 ℃; for 0.5h;

Reference yield:

: 1353636-05-1,909912-11-4
6-benzyloxy-7-methoxy-3-nitro-1H-quinolin-4-one

: 1360628-99-4
4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 100 °C

2: acetic acid / 18 h / 50 °C

3: tin(II) chloride dihdyrate / ethanol / 0.5 h / 70 °C

With tin(II) chloride dihdyrate; acetic acid; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1360628-99-4
4-(3-amino-6-benzyloxy-7-methoxyquinolin-4-yl-amino)-3-fluorobenzonitrile

: 2-trimethylsilanylethyl {2-[1-(4-cyano-2-fluorophenyl)-7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yloxy]-2-thiophen-2-ylethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

4: di-isopropyl azodicarboxylate; 2-(diphenylphosphino)pyridine / tetrahydrofuran / 0.25 h / 20 °C

With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;