3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

Base Information

Chemical Name:3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile
CAS No.:1360628-66-5
Molecular Formula:C₂₄H₁₇FN₄O₃S
Molecular Weight:460.488
Hs Code.:

Synonyms:3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

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Chemical Property of 3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

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Technology Process of 3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

There total 8 articles about 3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2746-23-8
3-(chloromethyl)thiophene

: 1360628-57-4
3-fluoro-4-(8-hydroxy-7-methoxy-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

: 1360628-66-5
3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1360628-62-1
4-(8-benzyloxy-7-methoxy-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-fluorobenzonitrile

: 1360628-66-5
3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

With boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1360628-98-3
4-(6-benzyloxy-7-methoxy-3-nitro-quinolin-4-yl-amino)-3-fluorobenzonitrile

: 1360628-66-5
3-fluoro-4-(7-methoxy-3-methyl-2-oxo-8-(thiophen-3-ylmethoxy)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tin(II) chloride dihdyrate / ethanol / 0.5 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4: boron tribromide; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

5: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

With tin(II) chloride dihdyrate; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;