2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide

Base Information

• Chemical Name: 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide
• CAS No.: 1382131-93-2
• Molecular Formula: C₁₈H₁₄FN₅O₂S
• Molecular Weight: 383.406

Synonyms:2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide

Chemical Property of 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide

Chemical Property:

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Technology Process of 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide

There total 6 articles about 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazole-2-thiol (332128-57-1) + 2-chloro-N-(4-fluorophenyl)acetamide (351-04-2) → 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide (1382131-93-2)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.ejmech.2012.03.033

Reference yield:

2-(1H-benzo[d]imidazol-1-yl)acetohydrazide (97420-39-8) → 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide (1382131-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 0 °C / Reflux

2: potassium carbonate / acetone / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetone;

DOI:10.1016/j.ejmech.2012.03.033

Reference yield:

4-fluoroaniline (371-40-4) → 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide (1382131-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: potassium carbonate / acetone / Reflux

With potassium carbonate; In acetone;

DOI:10.1016/j.ejmech.2012.03.033

upstream raw materials:

benzoimidazole

2-(1H-benzo[d]imidazol-1-yl)acetohydrazide

5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazole-2-thiol

2-chloro-N-(4-fluorophenyl)acetamide

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