5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

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Chemical Name:5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one
CAS No.:1431855-46-7
Molecular Formula:C₂₇H₂₀Cl₂N₄O₃S
Molecular Weight:551.453
Hs Code.:

Synonyms:5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

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Chemical Property of 5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

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Technology Process of 5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

There total 4 articles about 5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 618098-88-7
C₁₆H₁₀Cl₂N₂O

: 1431855-48-9
2-(2,4-dimethoxyphenylamino)thiazol-4-one

: 1431855-46-7
5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

Guidance literature:: With sodium acetate; In acetic acid; for 4h; Reflux;
DOI:10.1016/j.bmc.2012.12.053

Reference yield:

: 2735-04-8,161687-55-4
2,4-Dimethoxyaniline

: 1431855-46-7
5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: ethanol / 1.5 h / Reflux

3: sodium acetate / acetic acid / 4 h / Reflux

With sodium acetate; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.12.053

Reference yield:

: N-[1-(2,4-dichloro-phenyl)-ethylidene]-N'-phenyl-hydrazine

: 1431855-46-7
5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 6 h / 70 - 80 °C

2: sodium acetate / acetic acid / 4 h / Reflux

With sodium acetate; In acetic acid; N,N-dimethyl-formamide; 1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmc.2012.12.053