2-chloro-N-(2,4-dimethoxyphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2,4-dimethoxyphenyl)acetamide
• CAS No.: 101908-41-2
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 229.663
• Hs Code.: 2924299090
• European Community (EC) Number: 808-795-3
• NSC Number: 193511
• DSSTox Substance ID: DTXSID20307629
• Nikkaji Number: J2.431.600I
• Wikidata: Q82055098
• Mol file: 101908-41-2.mol

Synonyms:2-chloro-N-(2,4-dimethoxyphenyl)acetamide;101908-41-2;N1-(2,4-dimethoxyphenyl)-2-chloroacetamide;MFCD00750873;N-(2,4-dimethoxyphenyl)-2-chloroacetamide;Acetamide,2-chloro-N-(2,4-dimethoxyphenyl)-;NSC193511;SCHEMBL1494291;DTXSID20307629;SPDLCISEBHCEFN-UHFFFAOYSA-N;N-chloroacetyl-2,4-dimethoxyaniline;BBL008335;STK399046;AKOS000268703;NSC-193511;SB76959;BS-10261;CS-0443426;FT-0642463;2-Chloro-N-(2,4-dimethoxy-phenyl)-acetamide;EN300-01804;D85842;A919989;Z56869413

Chemical Property of 2-chloro-N-(2,4-dimethoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 4.84E-06mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 382.1 °C at 760 mmHg
• Flash Point: 184.9 °C
• PSA: 47.56000
• Density: 1.262 g/cm³
• LogP: 1.95410
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 229.0505709
• Heavy Atom Count: 15
• Complexity: 213

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(2,4-dimethoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)NC(=O)CCl)OC

Technology Process of 2-chloro-N-(2,4-dimethoxyphenyl)acetamide

There total 6 articles about 2-chloro-N-(2,4-dimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

chloroacetyl chloride (79-04-9) + 2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → 2-chloro-N-(2,4-dimethoxyphenyl)acetamide (101908-41-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.12.053

Reference yield:

O-methylresorcine (150-19-6) → 2-chloro-N-(2,4-dimethoxyphenyl)acetamide (101908-41-2)

Guidance literature:

Multi-step reaction with 6 steps

2: hydrogen sulfide; aqueous ammonia

3: acetic acid

4: alkaline solution

5: diluted hydrochloric acid

6: acetic acid; sodium acetate

With hydrogenchloride; ammonium hydroxide; alkaline solution; hydrogen sulfide; sodium acetate; acetic acid;

Reference yield:

N-(2,4-dimethoxyphenyl)acetamide (23042-75-3) → 2-chloro-N-(2,4-dimethoxyphenyl)acetamide (101908-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diluted hydrochloric acid

2: acetic acid; sodium acetate

With hydrogenchloride; sodium acetate; acetic acid;

upstream raw materials:

chloroacetyl chloride

2,4-Dimethoxyaniline

O-methylresorcine

N-(2,4-dimethoxyphenyl)acetamide

Downstream raw materials:

C₂₆H₃₂N₄O₅S

2-(2,4-dimethoxyphenylamino)-5-[3-(2,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]thiazol-4-one

5-[3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

5-[3-(2-chlorophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-2-(2,4-dimethoxyphenylamino)thiazol-4-one

Refernces

• 1、 Booher,Kornfeld,Smalstig,Clemens. "Synthesis of D-oxa tricyclic partial ergolines as dopamine agonists". . p. 580 - 583. Retrieved 1987.
• 2、 Myannik,Yarovenko,Rodionova,Baryshnikova,Krayushkin. "A convenient modified synthesis of 5-pyridinyl-1,3,4-thiadiazole-2-carboxamides". . p. 316 - 325. Retrieved 2017/10/16.
• 3、 Gawande, Shrikant S.,Warangkar, Suchita C.,Bandgar, Babasaheb P.,Khobragade, Chandrahasya N.. "Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase". . p. 2772 - 2777. Retrieved 2013/06/26.