<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Base Information

Chemical Name:<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine
CAS No.:131447-10-4
Molecular Formula:C₂₂H₃₇NO₆S₂
Molecular Weight:475.671
Hs Code.:

Synonyms:<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Suppliers and Price of <2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

There total 21 articles about <2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 131447-09-1
<2S,2(2R),2(3S),6S>-N-Benzyl-2-<2,3-(dihydroxy)heptyl>-6-methylpiperidine

: 124-63-0
methanesulfonyl chloride

: 131447-10-4
<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃;
DOI:10.1016/S0040-4039(00)97807-9

Reference yield:

: 138890-23-0
<3R,5R,5(1S)>-N-Benzyl-5-<1-(benzyloxy)pentyl>-3-<<(p-tolylsulfonyl)oxy>-methyl>isoxazolidine

: 131447-10-4
<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / NaI / butan-2-one / 5.5 h / 75 °C

2: 1) (2-thienyl)Cu(CN)Li / 1) THF, a) -78 deg C, 15 min, b) 0 deg C, 1.5 h, 2) a) -78 deg C, 15 min, b) 0 deg C, 1.5 h, c) room temp., 18 h

3: 90 percent / Zn dust, AcOH / H₂O; tetrahydrofuran / 2.5 h / 60 °C

4: 79 percent / 3.5 N Na₂CO₃ / CH₂Cl₂ / 1) 0 deg C, 30 min, 2) room temp., 2.5 h

5: 91 percent / O₂ / PdCl₂, CuCl₂ / dimethylformamide; H₂O / 50 °C

6: H₂ / 10percent Pd/C / methanol / 0.5 h

7: H₂, 10percent HCl / 10percent Pd/C / methanol / 2 h

8: Na₂CO₃ / dimethylformamide / 6 h / 70 °C

9: 76 percent / Et₃N / CH₂Cl₂ / 0.17 h / -20 °C

With hydrogenchloride; hydrogen; oxygen; sodium carbonate; acetic acid; thien-2-yl(cyano)copper lithium; triethylamine; sodium iodide; zinc; palladium on activated charcoal; copper dichloride; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; butanone;
DOI:10.1016/S0040-4020(01)80881-4

Reference yield:

: 131447-01-3
methyl <3R,5R,5(1S)>-N-benzyl-5-<1-(benzyloxy)pentyl>isoxazolidine-3-carboxylate

: 131447-10-4
<2S,2(2R),2(3S),6S>-N-Benzyl-2-<<2,3-di(methanesulfonyl)oxy>heptyl>-6-methylpiperidine

Guidance literature:: Multi-step reaction with 11 steps

1: 96 percent / LiAlH₄ / diethyl ether / 14 h / Ambient temperature

2: 97 percent / N,N-dimethylaminopyridine, diisopropylethylamine / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 80 percent / NaI / butan-2-one / 5.5 h / 75 °C

4: 1) (2-thienyl)Cu(CN)Li / 1) THF, a) -78 deg C, 15 min, b) 0 deg C, 1.5 h, 2) a) -78 deg C, 15 min, b) 0 deg C, 1.5 h, c) room temp., 18 h

5: 90 percent / Zn dust, AcOH / H₂O; tetrahydrofuran / 2.5 h / 60 °C

6: 79 percent / 3.5 N Na₂CO₃ / CH₂Cl₂ / 1) 0 deg C, 30 min, 2) room temp., 2.5 h

7: 91 percent / O₂ / PdCl₂, CuCl₂ / dimethylformamide; H₂O / 50 °C

8: H₂ / 10percent Pd/C / methanol / 0.5 h

9: H₂, 10percent HCl / 10percent Pd/C / methanol / 2 h

10: Na₂CO₃ / dimethylformamide / 6 h / 70 °C

11: 76 percent / Et₃N / CH₂Cl₂ / 0.17 h / -20 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; hydrogen; oxygen; sodium carbonate; acetic acid; thien-2-yl(cyano)copper lithium; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; zinc; palladium on activated charcoal; copper dichloride; palladium dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; butanone;
DOI:10.1016/S0040-4020(01)80881-4